Project Title: Genetic analysis of PRC1 function in homeostatic and malignant hematopoiesis.
Work Package(s) to which it is related: WP2.
Objectives and scientific expected results:
i) Phenotypic definition of RING1A/B and RYBP-deficient hematopoietic immortalization.
ii) Identification of transcriptome alterations and enhancers affected by PRC1 activity in immortal progenitors.