INSTITUT CURIE

INSTITUT CURIE

Institut Curie (IC), Genotoxic Stress and Cancer Unit, France

Christine TRAN QUANG and Jacques GHYSDAEL

Email: christine.tran-quang@curie.fr, jacques.ghysdael@curie.fr

Project Title: Hijacking developmental pathways as therapeutic targets in T-cell acute lymphoblastic leukemia (T-ALL).


Work Package(s) to which it is related : WP3.

Objectives and scientific expected results:
i) investigate therapeutic potential of blocking T-ALL/stroma interactions using CXCL12/CXCR4 inhibitors;
ii) characterize molecular pathways involved in the anti-leukemic properties of experimentally-induced persistent TCR activation in T-ALL.


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