Fondazione M. Tettamanti Menotti De Marchi, M. Tettamanti Research Center, Italy
Modeling the development and sustainment of pre-leukemia and leukemia target treatment.
Work Package(s) to which it is related : WP3.
Objectives and scientific expected results:
i) Modelling the BM microenviroment for investigating the interaction between pre-leukemic or leukemic cells and their niche.
ii) Frontline identification of targetable lesions in ALL patients and testing in vitro and in vivo the efficacy of new drugs in high-risk cases.