Institut Curie (IC), Genotoxic Stress and Cancer Unit, France
Christine TRAN QUANG and Jacques GHYSDAEL
Hijacking developmental pathways as therapeutic targets in T-cell acute lymphoblastic leukemia (T-ALL).
Work Package(s) to which it is related : WP3.
Objectives and scientific expected results:
i) investigate therapeutic potential of blocking T-ALL/stroma interactions using CXCL12/CXCR4 inhibitors;
ii) characterize molecular pathways involved in the anti-leukemic properties of experimentally-induced persistent TCR activation in T-ALL.
Andrea Ávila Ávila – PhD student