Max Planck Institute (MPG), Dept. of Cellular and Molecular Immunology, Germany
The aged dormant HSC compartment under homeostatic and stressed conditions.
Work Package(s) to which it is related : WP1.
Objectives and scientific expected results: the objective is to use our recently described mouse model that reversibly marks dormant HSCs avoiding label retaining assays (Cabezas-Wallscheid et al., Cell 2017) to address:
i) the evolution of the dormant HSC compartment from young towards aged hematopoiesis;
ii) address the ability of single aged dormant HSC to return to quiescence upon stress conditions.