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Project Title: Investigating the role of defective DNA repair mechanisms in HSC aging.
Work Package(s) to which it is related : WP1, WP2.
Objectives and scientific expected results: The objective is to use mouse progeria models to obtain molecular and cellular insight as to the involvement of DNA repair pathways in HSC aging. The expected results will include: (i) epigenomic and transcription factor occupancy maps in DNA repair defective aged HSCs; (ii) lineage commitment and differentiation potential of DNA defective HSCs; (iii) insight into potential transcriptional functions of DNA repair proteins in HSC aging.